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Dennis R Holmes, MD

Primary Location:
Address 1245 Wilshire Blvd, Suite 303
Los Angeles, CA 90017
Specialties: Breast Surgery Patient Rating Why don’t I see a star rating? Gender: Male


Dennis R. Holmes, M.D. is an internationally-renowned breast surgeon specializing in the surgical treatment of breast cancer and non-cancerous breast conditions. He completed his medical education at Tulane University School of Medicine, surgical residency in general surgery at the University of San Francisco, and a fellowship in breast surgery at the University of Southern California.

As a dedicated breast surgeon, Dr. Holmes has dedicated his career to breast cancer treatment innovation to reduce the burden of breast cancer care. He was a pioneering investigator in the TARGIT-A clinical trial that established the effectiveness of single-dose targeted intraoperative partial breast radiotherapy as an alternative to conventional 6-week daily whole breast radiotherapy. He currently serves as Co-Principal Investigator of the TARGIT U.S. Registry Trial and as President of the TARGIT Collaborative Group, a national organization of surgeons, radiation oncologists, and physicists committed to improving cancer patient care through education, patient advocacy, mentorship, and collaborative research. Dr. Holmes also serves as national principal investigator of the FROST trial, a multicenter trial evaluating the role of cryoablation or tumor freezing in the management of early stage breast cancer.

Dr. Holmes is a board-certified Fellow of the American College of Surgeons and currently holds the position of Program Chair of the 20th Annual National Meeting of the American Society of Breast Surgeons and co-chair of the Oncoplastic Surgery Committee, and chaired the development of the society’s performance and practice guideline for the use of neoadjuvant systemic therapy in the management of breast cancer.

As a sought-after physician educator, Dr. Holmes is a frequent lecturer at medical conferences around the globe. Most important to his patients, Dr. Holmes is a warm, caring breast surgeon who possesses the expertise, empathy and patience to help each patient find a breast cancer solution that suits her physically and emotionally, while providing the best possible cancer control.


  • American Board of Surgery, General Surgery, 2003


  • Internship

    Barnes Jewish Hospital

  • Internship

    University of California

  • Residency

    Barnes Jewish Hospital

  • Fellowship

    Keck School of Medicine at USC

  • Medical School

    Tulane University School of Medicine


  • Primary Location
    1245 Wilshire Blvd, Suite 303
    Los Angeles, CA 90017
    (818) 539-1985 Map and directions
  • Additional Location
    1505 Wilson Ter Ste 150
    Glendale, CA 91206
    (818) 539-1985 Map and directions
  • Additional Location
    2121 Santa Monica Blvd.
    Garden Level
    Santa Monica, CA 90404
    (310) 582-7107 Map and directions